Methicillin-resistant Staphylococcus aureus (MRSA) causes a number of different clinical presentations. Most MRSA infections involve the skin and subcutaneous tissues, producing manifestations such as boils, abscesses, rash, or blistering areas. Boils and abscesses are localized collections of pus as a result of the bacterial infection. The inflamed area may be reddened, tender, swollen, and warm to the touch. These signs can also appear in MRSA-infected surgical incisions. When MRSA infection spreads beyond these areas to involve the bloodstream, systemic (body-wide) symptoms occur. These can include fever, chills, low blood pressure, joint pains, severe headaches, shortness of breath, and widespread rash.